"An error has occurred while trying to create a virtualbox host-only network interface" (Linux)

1. Are you trying to run Genymotion Desktop in a virtual machine?

Using Genymotion Desktop in a virtual environment is not supported. See Can Genymotion Desktop run in a virtual machine?

2. Is VirtualBox kernel module properly installed?

1. Refer to the documentation from VirtualBox: https://www.virtualbox.org/manual/ch02.html#install-linux-host
2. Make sure that the dkms package is installed and that it compiles VirtualBox kernel modules each time a new kernel update is available. To do so, run:

   modinfo vboxdrv

   If the vboxdrv kernel module is loaded, it should return:
   

   filename:       /lib/modules/4.15.0-47-generic/misc/vboxdrv.ko
   version:        6.1.16_Ubuntu r140961 (0x00300000)
   ...

   If not, try to reload kernel modules manually by running

   sudo modprobe vboxdrv

   If the above doesn’t work, force VirtualBox kernel modules compilation.
   Ubuntu/Debian:
   

   sudo apt-get --reinstall install virtualbox-dkms

   Fedora:

   sudo /sbin/vboxconfig

If none of the above works, try to remove VirtualBox and re-install it. We strongly recommend using the package form your distribution repositories.

3. Restart your system

Try to reboot your system - VirtualBox usually requires a reboot after a fresh install.

4. Are you using a VPN and/or a firewall?

If so, please refer to Genymotion Desktop and VPN and Genymotion Desktop and firewalls