This error means that VirtualBox could not be configured properly. Try the following:
Windows
Delete the folder %HOMEPATH%\.VirtualBox and try again.
If it doesn't help, uninstall your current VirtualBox and re-install Virtual Recommended version.
Linux / macOS
VirtualBox is no longer recommended on Linux and macOS systems, and will be deprecated in the future. Please switch to QEMU hypervisor.
For detailed instructions, please refer to the Genymotion Desktop on-line documentation.