Genymotion Desktop needs to be able to create and access at least one host-only VirtualBox interface. Make sure that your Windows account has enough permissions to let VirtualBox create host-only interfaces.
Genymotion Desktop should not be run as administrator. Please verify the following:
- Make sure that Hyper-V is disabled. See Genymotion Desktop and Hyper-V (Windows 8/8.1/10).
- It may mean that VirtualBox has been installed with a different Windows account than the one you are currently using. If so, remove VirtualBox and re-install it from your windows user account.