"An error has occurred while trying to create a virtualbox host-only network interface" (macOS)

1. Mac M1 series

Genymotion Desktop is not compatible with the Apple Silicon CPU family yet.

For more information, please refer to Does Genymotion Desktop work on Mac M1?

2. Upgrade from a previous macOS version

If you recently updated to macOS 11 (Big Sur), please refer to Genymotion Desktop does not work since I upgraded to macOs Big Sur 11.0.1

3. macOS security

This issue may be due to security restrictions in macOS which blocks VirtualBox modules installation:

1. Uninstall VirtualBox (use the VirtualBox_uninstall.tool of the VirtualBox downloaded dmg from https://www.virtualbox.org/wiki/Downloads).
2. Open a terminal and restore SIP to default:
   

   sudo csrutil clear

3. Reboot macOS
4. Clear staging:
   

   sudo kextcache --clear-staging

5. Reboot macOS
6. Re-install VirtualBox from VirtualBox.pkg and follow system prompt to allow Oracle. If you don't get the system prompt, go to System Preferences > Security and Privacy, and then click the Allow button:
   

4. VPNs

If you are using a VPN, please refer to Genymotion Desktop and VPN