"An error has occurred while trying to create a virtualbox host-only network interface" (macOS)

This issue may be due to security restrictions in macOS which blocks VirtualBox modules installation:

1. Uninstall VirtualBox (use the VirtualBox_uninstall.tool of the VirtualBox downloaded dmg from https://www.virtualbox.org/wiki/Downloads).
2. Open a terminal and restore SIP to default:
   

   sudo csrutil clear

3. Reboot macOS
4. Clear staging:
   

   sudo kextcache --clear-staging

5. Reboot macOS
6. Re-install VirtualBox from VirtualBox.pkg and follow system prompt to allow Oracle. If you don't get the system prompt, go to System Preferences > Security and Privacy, and then click the Allow button:
   

If you are using a VPN, please refer to Genymotion Desktop and VPN