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macOS - An error has occurred while trying to create a virtualbox host-only network interface

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1. You are running Genymotion Desktop in a virtual machine

Genymotion Desktop has been designed to run in a physical environment, not in a virtual machine. For this reason, Genymotion Desktop will not work if run in a macOS Virtual Machine.

For more details, please refer to Can Genymotion Desktop run in a virtual machine?

2. Your mac is a Mac M1 series

Genymotion Desktop 3.2.1 requires VirtualBox for virtualization, but it is not compatible with the Apple Silicon CPU family yet.

For more information, please refer to Does Genymotion Desktop work on Mac M1?

3. You have upgraded macOS

If you upgraded to macOS 11 (Big Sur), please refer to Genymotion Desktop does not work since I upgraded to macOs Big Sur 11.0.1

If you upgraded to macOS 12 (Monterey), please note that Genymotion Desktop is not functional with this version yet. For more details, see Genymotion Desktop does not work since I upgraded to macOs Monterey 12.0.1

4. macOS security blocked VirtualBox kernel installation

This issue may be due to security restrictions in macOS which blocks VirtualBox modules installation.

Method 1

  1. Go to System Preferences > Security and Privacy, and then click the Allow button:
    macos_security.png
  2. Reboot macOS

Method 2

If VirtualBox has already been installed and you don't see the message System software from developer "Oracle America, Inc." was blocked from loading, follow these steps:

  1. Uninstall VirtualBox and reinstall it.
  2. Go to System Preferences > Security and Privacy, and then click the Allow button:
    macos_security.png
  3. Reboot macOS

Method 3

If Method 2 fails, follow these steps:

  1. Uninstall VirtualBox (use the VirtualBox_uninstall.tool of the VirtualBox downloaded dmg from https://www.virtualbox.org/wiki/Downloads).
  2. Open a terminal and restore SIP to default:
    sudo csrutil clear
  3. Reboot macOS
  4. Clear staging:
    sudo kextcache --clear-staging
  5. Reboot macOS
  6. Re-install VirtualBox from VirtualBox.pkg and follow system prompt to allow Oracle. If you don't get the system prompt, go to System Preferences > Security and Privacy, and then click the Allow button:
    macos_security.png
  7. Reboot macOS

4. You are using a VPN and/or a firewall

Please refer to these articles:

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