macOS - An error has occurred while trying to create a virtualbox host-only network interface

1. You are trying to run Genymotion Desktop in a virtual machine, a mac server or a macOS Cloud instance (AWS, GCP, Azure, ...)

Genymotion Desktop has been designed to run in a physical environment, not in a virtual machine. For this reason, Genymotion Desktop will not work if run in a macOS Virtual Machine, a mac server nor a macOS Cloud instance.

For more details, please refer to the following articles:

• Can Genymotion Desktop run in a virtual machine?
• Can Genymotion Desktop run on a server?
• Can Genymotion Desktop run in a Cloud service (AWS, Google Cloud, MS Azure, Alibaba, etc.)?

2. Your Mac model has been released after 2020

Genymotion Desktop 3.2 requires VirtualBox for virtualization which is not compatible with the Apple Silicon CPU family (VirtualBox is a x86/x86_64 hypervisor).

For more information, please refer to Genymotion Desktop and Apple M1 SoC Mac series

3. You have recently upgraded macOS

Please refer to the following articles:

• Genymotion Desktop does not work since I upgraded to macOs Big Sur 11.0.1
• Genymotion Desktop does not work since I upgraded to macOs Monterey 12.0.1

4. macOS security blocked VirtualBox kernel installation

This issue may be due to security restrictions in macOS which blocks VirtualBox modules installation.

Method 1

1. Go to System Preferences > Security & Privacy > General, and then click the Allow button:
   
2. Reboot macOS

Method 2

If VirtualBox has already been installed and you don't see the message System software from developer "Oracle America, Inc." was blocked from loading, follow these steps:

1. Uninstall VirtualBox and reinstall it.
2. Go to System Preferences > Security & Privacy > General, and then click the Allow button:
   
3. Reboot macOS

Method 3

If Method 2 fails, follow these steps:

1. Uninstall VirtualBox (use the VirtualBox_uninstall.tool of the VirtualBox downloaded dmg from https://www.virtualbox.org/wiki/Downloads).
2. Open a terminal and restore SIP to default:
   

   sudo csrutil clear

3. Reboot macOS
4. Clear staging:
   

   sudo kextcache --clear-staging

5. Reboot macOS
6. Re-install VirtualBox from VirtualBox.pkg and follow system prompt to allow Oracle. If you don't get the system prompt, go to System Preferences > Security & Privacy > General, and then click the Allow button:
   
7. Reboot macOS

4. You are using a VPN and/or a firewall

Please refer to these articles:

• Genymotion Desktop and VPN
• Genymotion Desktop and firewalls