This is a known bug with Windows 10. Unfortunately, no fixes could be implemented so far.
If you experience VRAM and/or RAM leakage when using Genymotion Desktop on Windows 10, please try on a different OS such as Linux or macos.
For more information on Genymotion Desktop compatible and recommended operating systems, please refer to Supported operating systems
Due to this bug, Genymotion Desktop is not suitable for automated and/or scale tests. Instead, we have specifically designed our Cloud products for such usage.
For more information, please visit https://www.genymotion.com/cloud/