This may be caused by Hyper-V which interferes with VirtualBox. Try to disable Hyper-V. For detailed instructions, please refer to Genymotion Desktop and Hyper-V (Windows 8/8.1/10)
If this does not apply to you, then Genymotion Desktop may be corrupted or not correctly installed.
Try to uninstall/purge Genymotion Desktop and re-install it. To do so, please follow instructions from How to uninstall Genymotion Desktop completely (purge)?